Reprogramming Stars #10:Modeling Cancer with Cellular Reprogramming—An Interview with Dr. Dung-Fang Lee

Reprogramming Star: Dr. Dung-Fang Lee is an assistant professor and CPRIT scholar in cancer research at the University of Texas Health Science Center at Houston. The Lee research laboratory is dedicated to understanding the pathological mechanisms behind cancer by applying patient-specific induced pluripotent stem cells (iPSCs) and/or engineered embryonic stem cells (ESCs) as models. The central directions of the Lee laboratory include (1) systems-level analyses and characterization of mutant p53 in Li–Fraumeni syndrome-associated tumor initiation, (2) systematic analyses of genome alterations during Li–Fraumeni syndrome-associated osteosarcoma development, and (3) modeling of familial cancer syndromes with a predisposition to osteosarcoma through patient-specific iPSC methods.