Reprogramming Stars #11: Teaming Up to Uncoverthe Epitranscriptomics of Reprogramming—An Interview with Dr. Miguel Fidalgo and Dr. Diana Guallar

Reprogramming Stars: Dr. Diana Guallar is an Assistant Professor at the Department of Biochemistry and Molecular Biology in the University of Santiago de Compostela (USC) and group leader at the Center for Research in Molecular Medicine and Chronic Diseases (CIMUS). The Guallar laboratory studies how epigenetic and epitranscriptomic cross talk is involved in the regulation of cell identity and plasticity in cellular rejuvenation and pluripotency. Her ultimate aim is to dissect critical pathways accompanying the loss of molecular fidelity observed during aging and in aging-related disorders that could be very valuable for clinical application. Dr. Miguel Fidalgo is an Associate Professor at the Department of Physiology (USC) and group leader at the CIMUS. The Fidalgo laboratory is focused on understanding how regulatory information encoded by the genome is integrated with the metabolic, epigenetic, and epitranscriptomic machineries to control cellular plasticity in the context of cell reprogramming and pluripotency, and how perturbations of these mechanisms could be associated with development and disease.