A combinatorial transcription factor screening platform for immune cell reprogramming

Ilia Kurochkin, Abigail R. Altman, Inês Caiado, Diogo Pértiga-Cabral, Evelyn Halitzki, Mariia Minaeva, Olga Zimmermannová, Luís Henriques-Oliveira, Dominik Klein, Malavika Nair, Daniel Oliveira, Laura Rabanal Cajal, Ramin Knittel, Cora Feick, Markus Ringnér, Marcel Martin, Branko Cirovic, Cristiana F. Pires, Fabio F. Rosa, Ewa Sitnicka, Fabian J. Theis, Carlos-Filipe Pereira

January 14, 2026 / 17
Cell Systems

Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity

Luís Henriques-Oliveira*, Abigail R. Altman*, Ilia Kurochkin*, Ervin Ascic, Evelyn Halitzki, Andreea-Medeea Matei, Diogo Pértiga-Cabral, Isabel Ulmert, Signe Holst, Malavika Sreekumar Nair, Pedro P. Cunha, Sun-Mi Park, Stefano Vergani, Michael G. Kharas, Joan Yuan, Katharina Lahl, Fábio F. Rosa, Cristiana F. Pires, Carlos-Filipe Pereira

August 29, 2025 / 58
Immunity

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells

Ervin Ascic, Gaia Fontanari, Maria Thrasyvoulou, César Pérez Bucio, Tommaso Ballocci, Carlos-Filipe Pereira

August 1, 2025
JoVE

RORγt-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells

Hamsa Narasimhan, Maria L Richter, Ramin Shakiba, Nikos E Papaioannou, Christina Stehle, Kaushikk Ravi Rengarajan, Isabel Ulmert, Arek Kendirli, Clara de la Rosa, Pin-Yu Kuo, Abigail Altman, Philipp Münch, Saba Mahboubi, Vanessa Küntzel, Amina Sayed, Eva-Lena Stange, Jonas Pes, Alina Ulezko Antonova, Carlos-Filipe Pereira, Ludger Klein, Diana Dudziak, Marco Colonna, Natalia Torow, Mathias W Hornef, Björn E Clausen, Martin Kerschensteiner, Katharina Lahl, Chiara Romagnani, Maria Colomé-Tatché, Barbara U Schraml

February 24, 2025 / Volume 122, Number 9
PNAS

Transcription Factor–Mediated Reprogramming to Antigen-Presenting Cells

Ervin Ascic, Carlos-Filipe Pereira

January 7, 2025
Current Opinion in Genetics & Development

HMGA1 stimulates cancer stem-like features and sensitivity to monensin in gastric cancer

Diana Pádua, Paula Figueira, António Pombinho, Inês Monteiro, Carlos Filipe Pereira, Raquel Almeida, Patrícia Mesquita

October 1, 2024 / Volume 442, Issue 2
Experimental Cell Research

In Vivo Dendritic Cell Reprogramming for Cancer Immunotherapy

Ervin Ascic, Fritiof Åkerström, Malavika Sreekumar Nair, André Rosa, Ilia Kurochkin, Olga Zimmermannova, Xavier Catena, Nadezhda Rotankova, Charlotte Veser, Michal Rudnik, Tommaso Ballocci, Tiffany Schärer, Xiaoli Huang, Maria de Rosa Torres, Emilie Renaud, Marta Velasco Santiago, Özcan Met, David Askmyr, Malin Lindstedt, Lennart Greiff, Laure-Anne Ligeon, Irina Agarkova, Inge Marie Svane, Cristiana F. Pires, Fábio F. Rosa, and Carlos-Filipe Pereira

September 5, 2024
Science

Genomic deletion of Bcl6 differentially affects conventional dendritic cell subsets and compromises Tfh/Tfr/Th17 cell responses

Hongkui Xiao, Isabel Ulmert, Luisa Bach, Johanna Huber, Hamsa Narasimhan, Ilia Kurochkin, Yinshui Chang, Signe Holst, Urs Mörbe, Lili Zhang, Andreas Schlitzer, Carlos-Filipe Pereira, Barbara U Schraml, Dirk Baumjohann, Katharina Lahl

April 30, 2024
Nature Communications

Orchestrating an Immune Response to Cancer with Cellular Reprogramming

Olga Zimmermannova, Alexandra Gabriela Ferreira & Carlos-Filipe Pereira

December 15, 2023
Genes & Immunity

Reprogramming Cancer Cells to Antigen-presenting Cells

Alexandra G Ferreira, Olga Zimmermannova, Ilia Kurochkin, Ervin Ascic, Fritiof Åkerström, Carlos-Filipe Pereira

November 20, 2023 / Volume 13, Issue 22
Bio-protocol