Alexandra Gabriela Ferreira

PhD Student

Restoring Antitumour Immunity with Dendritic Cell Reprogramming Strategies


After her bachelors in Biomedical Sciences, Gabriela has pursued a Master’s in Molecular Genetics during which she has developed a project aiming at the direct reprogramming of fibroblasts to regulatory T cells. Currently, on her PhD studies, Gabriela is exploring direct reprogramming strategies to generate novel cancer immunotherapies. First she has improved the direct reprogramming of dendritic cells by building polycistronic vectors with Spi1, Irf8 and Batf3. For the past two years she has been working on reprogramming cancer cells to antigen presenting cells.
Gabriela’s main goal is to translate it into the mouse system and later to the human to demonstrate that reprogramming cancer cells with dendritic cell factors potentiates antitumour immunity in vivo.

Scientific Events

  • SPI Annual Meeting 2017;
  • 5th Swedish Cancer Research Meeting 2019

Public Outreach

  • Immunology Day 2017 @UC-Biotech

Academic Background

  • MSc in Molecular Genetics, University of Minho (Portugal);
  • BSc in Biomedical Sciences, University of Beira Interior (Portugal).


Single-Cell Transcriptional Profiling Informs Efficient Reprogramming of Human Somatic Cells to Cross-Presenting Dendritic Cells

Fábio F. Rosa, Cristiana F. Pires, Ilia Kurochkin, Evelyn Halitzki, Tasnim Zahan, Nejc Arh, Olga Zimmermannová, Alexandra G. Ferreira, Hongzhe Li, Stefan Karlsson, Stefan Scheding, Carlos-Filipe Pereira

March 4, 2022 / Vol. 7, No. 69
Science Immunology

Cell Fate Reprogramming in the Era of Cancer Immunotherapy

Olga Zimmermannova, Inês Caiado, Alexandra G. Ferreira and Carlos-Filipe Pereira

July 21, 2021 / Volume 12, Article 714822
Frontiers in Immunology

Direct Reprogramming of Fibroblasts into Antigen-Presenting Dendritic Cells

Fábio F. Rosa, Cristiana F. Pires, Ilia Kurochkin, Alexandra G. Ferreira, Andreia M. Gomes, Luís G. Palma, Kritika Shaiv, Laura Solanas, Cláudia Azenha, Dmitri Papatsenko, Oliver Schulz, Caetano Reis e Sousa and Carlos-Filipe Pereira

December 7, 2018 / Vol. 3, Issue 30, eaau4292
Science Immunology

Generating a Personalized Immunotherapy by Reprogramming Fibroblasts to Regulatory T Cells

Alexandra Gabriela Barros Ferreira

March 14, 2017
MSc. Thesis - University of Minho