Pereira Lab on the News for Discovering the Origin of Blood Stem Cells

The Pereira Lab team has been covered on the Portuguese News on their published research on the origin of blood stem cells. The work published on Developmental Cell has captured the attention of Portuguese television and newspapers.

Building upon previous work, researchers at Pereira Lab identified cells in the embryos of mice that are precursors to blood stem cells or hematopoietic stem/progenitor cells (HSPCs). In previous studies, they reprogrammed mouse skin cells in the lab to become HSPCs. Now, they have identified a precursor cell in the placenta and embryo of mice that can be matured in the lab to make HSPCs. Their study, titled, “Hematopoietic Reprograming In Vitro Informs in Vivo Identification of Hemogenic Precursors to Definitive Hematopoietic Stem Cells,” establishes that the reprogramming process can work back and forth in blood cell development. Their results, published in the journal Developmental Cell, could eventually lead to a process of developing patient-specific HSPCs and more differentiated blood products for cell-replacement therapy.

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