Mechanism for turning skin cells into blood stem cells uncovered

Human skin cells have been converted successfully into blood stem cells at the Pereira Lab, bringing new therapies for people with blood diseases a step closer. This international project – including scientist from Sweden, USA, Russia, and Portugal – follows our previous research on the reprogramming of mouse skin cells into blood stem cells. In this study we shift our focus from the specification of mouse to human hematopoietic stem cells. We describe the generation of hemogenic precursors from human fibroblasts via an endothelial intermediate and highlight the general importance of transcription factor cooperation during human hematopoietic stem cell specification.

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