Filipe Pereira, PhD
Filipe Pereira has long held an interest in understanding how cell identity is acquired, maintained and ultimately modified or reversed. During his PhD, he has made his first contributions to the cellular reprogramming field by establishing cell fusion and heterokaryons as a new method to study reprogramming mechanisms towards pluripotency. Then, during his postdoc, he brought cellular reprogramming concepts to hematopoeisis for the first time.
His independent research group has now shown that cooperative transcription factor binding mediates hemogenic induction and pioneered
cell fate reprogramming approaches in immunology with induced dendritic cells. This conceptual shift opens exciting opportunities to merge cellular reprogramming and cancer immunotherapy that his research group will explore during the next years.
The therapeutic potential of these approaches led him to become the co-founder of the spin-off company Asgard Therapeutics AB with support of LU Innovation and LU Holding. Tight collaboration between his research group and Asgard Therapeutics will be critical for translating research findings into new cancer immunotherapies.
In the Media
- 2019 – Docent in Molecular Medicine at Lund University.
- 2009 – PhD in Biomedical Sciences. Imperial College School of Medicine, London, U.K.
- 2002 – Graduation in Biology (4-year degree). Faculty of Sciences, University of Porto, Portugal.
- 2019 – Associate Professor and Group Leader. Faculty of Medicine, Lund University, Sweden.
- 2017 – 2019 Assistant Professor and Group Leader. Faculty of Medicine, Lund University, Sweden.
- 2015 – Assistant Professor and Group Leader. Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Portugal.
- 2010 – 2015 Postdoctoral Fellow at Prof. Ihor R. Lemischka and Kateri Moore laboratory. Department of Developmental and Regenerative Biology, Mount Sinai, New York, USA.
- 2009 – 2010 Postdoctoral Fellow at Prof. Amanda G. Fisher laboratory. MRC Clinical Sciences Centre, Imperial College School of Medicine, London, UK.
- 2004 – 2009 Graduate Student at Prof. Amanda G. Fisher laboratory. MRC Clinical Sciences Centre, Imperial College School of Medicine, London, UK.
- 2002 – 2003 Research Assistant at Dr. Fernando Arosa laboratory, Lymphocyte Biology Group. Institute for Cellular and Molecular Cell Biology, Porto University, Porto, Portugal.
Single-Cell Transcriptional Profiling Informs Efficient Reprogramming of Human Somatic Cells to Cross-Presenting Dendritic Cells
Fábio F. Rosa, Cristiana F. Pires, Ilia Kurochkin, Evelyn Halitzki, Tasnim Zahan, Nejc Arh, Olga Zimmermannová, Alexandra G. Ferreira, Hongzhe Li, Stefan Karlsson, Stefan Scheding, Carlos-Filipe Pereira
March 4, 2022 / Vol. 7, No. 69
Cell Fate Reprogramming in the Era of Cancer Immunotherapy
Olga Zimmermannova, Inês Caiado, Alexandra G. Ferreira and Carlos-Filipe Pereira
July 21, 2021 / Volume 12, Article 714822
Frontiers in Immunology
Mononuclear Phagocyte Regulation by the Transcription Factor Blimp-1 in Health and Disease
Isabel Ulmert, Luís Henriques‐Oliveira, Carlos‐Filipe Pereira, Katharina Lahl
August 16, 2020
Direct Reprogramming of Mouse Embryonic Fibroblasts to Conventional Type 1 Dendritic Cells by Enforced Expression of Transcription Factors
Fábio F. Rosa, Cristiana F. Pires, Olga Zimmermannova and Carlos-Filipe Pereira
May 20, 2020 / Volume 10, Issue 10
A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells
Diana Pádua, Rita Barros, Ana Luísa Amaral, Patrícia Mesquita, Ana Filipa Freire, Mafalda Sousa, André Filipe Maia, Inês Caiado, Hugo Fernandes, António Pombinho, Carlos Filipe Pereira and Raquel Almeida
February 20, 2020 / Volume 12, Issue 2
Is Immunotherapy the Holy Grail for Pancreatic Cancer?
Roland Andersson, Carlos-Filipe Pereira, Monika Bauden, Daniel Ansari
November 21, 2019 / Volume 11, Issue 17
Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors
Rita Silvério-Alves, Andreia M. Gomes, Ilia Kurochkin, Kateri A. Moore, Carlos-Filipe Pereira
November 4, 2019 / Issue 153
Journal of Visualized Experiments: Jove
Induction of Human Hemogenesis in Adult Fibroblasts by Defined Factors and Hematopoietic Coculture
Michael G. Daniel, David Sachs, Jeffrey M. Bernitz, Yesai Fstkchyan, Katrina Rapp, Namita Satija, Kenneth Law, Foram Patel, Andreia M. Gomes, Huen‐Suk Kim, Carlos‐Filipe Pereira Benjamin Chen, Ihor R. Lemischka, Kateri A. Moore
September 26, 2019 / 593(23):3266-3287
Direct Reprogramming of Fibroblasts into Antigen-Presenting Dendritic Cells
Fábio F. Rosa, Cristiana F. Pires, Ilia Kurochkin, Alexandra G. Ferreira, Andreia M. Gomes, Luís G. Palma, Kritika Shaiv, Laura Solanas, Cláudia Azenha, Dmitri Papatsenko, Oliver Schulz, Caetano Reis e Sousa and Carlos-Filipe Pereira
December 7, 2018 / Vol. 3, Issue 30, eaau4292
Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming
Andreia M Gomes, Ilia Kurochkin, Betty Chang, Michael Daniel, Kenneth Law, Namita Satija, Alexander Lachmann, Zichen Wang, Lino Ferreira, Avi Ma'ayan, Benjamin K Chen, Dmitri Papatsenko, Ihor R Lemischka, Kateri A Moore, Carlos-Filipe Pereira
December 4, 2018 / Vol. 25, Issue 10
Compositions for Reprogramming Cells into Dendritic Cells or Antigen Presenting Cells, Methods and Uses Thereof
Fábio F. Rosa, Cristiana F. Pires, Carlos-Filipe Pereira
October 13, 2018
High-throughput Identification of Small Molecules that Affect Human Embryonic Vascular Development
Helena Vazão, Susana Rosa, Tânia Barata, Ricardo Costa, Patrícia R. Pitrez, Inês Honório, Margreet R. de Vries, Dimitri Papatsenko, Rui Benedito, Daniel Saris, Ali Khademhosseini, Paul H. A. Quax, Carlos F. Pereira, Nadia Mercader, Hugo Fernandes, and Lino Ferreira
April 11, 2017 / Volume 114, Issue 15
Method for Programming Differentiated Cells into Hematopoietic Stem Cells
Carlos-Filipe Pereira, Kateri A Moore, Ihor R. Lemischka
January 10, 2017
Hematopoietic Reprogramming In Vitro Informs In Vivo Identification of Hemogenic Precursors to Definitive Hematopoietic Stem Cells
Carlos-Filipe Pereira, Betty Chang, Andreia Gomes Jeffrey Bernitz, Dmitri Papatsenko, Xiaohong Niu, Gemma Swiers, Emanuele Azzoni, Marella F.T.R. de Bruijn, Christoph Schaniel, Ihor R. Lemischka, Kateri A. Moore
March 7, 2016 / Volume 36, Issue 5
Making a Hematopoietic Stem Cell
Michael G Daniel, Carlos-Filipe Pereira, Ihor R Lemischka, Kateri A Moore
March 1, 2016 / Volume 26, Issue 3
Trends in Cell Biology
‘From Blood to Blood’: De-differentiation of Hematopoietic Progenitors to Stem Cells
Carlos‐Filipe Pereira, Ihor R Lemischka, Kateri Moore
July 17, 2014 / Volume 33, Issue 14
The EMBO Journal
Induction of a Hemogenic Program in Mouse Fibroblasts
Carlos-Filipe Pereira, Betty Chang, Jiajing Qiu, Xiaohong Niu, Dmitri Papatsenko, Caroline E Hendry, Neil R Clark, Aya Nomura-Kitabayashi, Jason C Kovacic, Avi Ma'ayan, Christoph Schaniel, Ihor R Lemischka, Kateri Moore
August 1, 2013 / Volume 13, Issue 2
Cell Stem Cell
Reprogramming Cell Fates: Insights from Combinatorial Approaches
Carlos-Filipe Pereira, Ihor R Lemischka, Kateri Moore
August 17, 2012 / Volume 1266
Annals of the New York Academy of Sciences