Filipe Pereira, PhD

Team

Group Leader

Biography

Filipe Pereira, Ph.D. is a Professor of Molecular Medicine in the Faculty of Medicine at Lund University in Sweden. Dr. Pereira is recognized for his work at the interface of cellular reprogramming and immunology and for fostering development of reprogramming-based immunotherapies.

For the last 20 years he has contributed to the fields of cellular reprogramming and hematopoietic specification. Dr. Pereira received his Ph.D. at Imperial College London where he established cell fusion and heterokaryons to study mechanisms of reprogramming towards pluripotency. During his postdoctoral training at the Icahn School of Medicine at Mount Sinai in New York, he brought cellular reprogramming concepts to hematopoeisis for the first time. Dr. Pereira started his independent group at Lund University in 2017 and has uncovered new mechanisms underlying hematopoietic reprogramming and definitive hematopoiesis specification. He pioneered cellular reprogramming approaches in immunology by inducing dendritic cells from fibroblasts and cancer cells. This conceptual shift opened exciting opportunities to merge cellular reprogramming and cancer immunotherapy. Dr. Pereira co-founded Asgard Therapeutics, which received investment from leading European VCs to translate in vivo dendritic cell reprogramming to benefit cancer patients.

For his scientific accomplishments and innovation efforts, he received several notable scientific awards, including ERC Consolidator and Proof-of-Concept Grants, the Novo Nordisk Foundation Distinguished Innovator Grant and the entrepreneurship award from Mount Sinai-KiiLN. Dr. Pereira is a fellow of the Swedish Wallenberg program in Molecular Medicine and Editor-in-Chief of the journal Cellular Reprogramming. He was also awarded a medal of merit from his hometown in Portugal.

Spin-Off Co-Founder

In the Media

_{Filipe’s Publications at Google Scholar}

Academic Background

2019 – Docent in Molecular Medicine at Lund University, Sweden.
2009 – PhD in Biomedical Sciences. Imperial College School of Medicine, London, U.K.
2002 – BSc in Biology (4-years). Faculty of Sciences, University of Porto, Portugal.

Positions

2022 – Professor and Group Leader. Faculty of Medicine, Lund University, Sweden.
2019 – 2022 Associate Professor and Group Leader. Faculty of Medicine, Lund University, Sweden.
2017 – 2019 Assistant Professor and Group Leader. Faculty of Medicine, Lund University, Sweden.
2015 – Assistant Investigator and Group Leader. CNC – Center for Neurosciences and Cell Biology, University of Coimbra, Portugal.
2010 – 2015 Postdoctoral Fellow at Prof. Ihor R. Lemischka and Kateri Moore laboratory. Department of Developmental and Regenerative Biology, Mount Sinai, New York, USA.
2009 – 2010 Postdoctoral Fellow at Prof. Amanda G. Fisher laboratory. MRC Clinical Sciences Centre, Imperial College School of Medicine, London, UK.
2004 – 2009 Graduate Student at Prof. Amanda G. Fisher laboratory. MRC Clinical Sciences Centre, Imperial College School of Medicine, London, UK.
2002 – 2003 Research Assistant at Dr. Fernando Arosa laboratory, Lymphocyte Biology Group. Institute for Cellular and Molecular Cell Biology, Porto University, Porto, Portugal.

Publications

In Vivo Dendritic Cell Reprogramming for Cancer Immunotherapy

Ervin Ascic, Fritiof Åkerström, Malavika Sreekumar Nair, André Rosa, Ilia Kurochkin, Olga Zimmermannova, Xavier Catena, Nadezhda Rotankova, Charlotte Veser, Michal Rudnik, Tommaso Ballocci, Tiffany Schärer, Xiaoli Huang, Maria de Rosa Torres, Emilie Renaud, Marta Velasco Santiago, Özcan Met, David Askmyr, Malin Lindstedt, Lennart Greiff, Laure-Anne Ligeon, Irina Agarkova, Inge Marie Svane, Cristiana F. Pires, Fábio F. Rosa, and Carlos-Filipe Pereira

September 5, 2024
Science

Orchestrating an Immune Response to Cancer with Cellular Reprogramming

Olga Zimmermannova, Alexandra Gabriela Ferreira & Carlos-Filipe Pereira

December 15, 2023
Genes & Immunity

Reprogramming Cancer Cells to Antigen-presenting Cells

Alexandra G Ferreira, Olga Zimmermannova, Ilia Kurochkin, Ervin Ascic, Fritiof Åkerström, Carlos-Filipe Pereira

November 20, 2023 / Volume 13, Issue 22
Bio-protocol

GATA2 Mitotic Bookmarking Is Required for Definitive Haematopoiesis

Rita Silvério-Alves, Ilia Kurochkin, Anna Rydström, Camila Vazquez Echegaray, Jakob Haider, Matthew Nicholls, Christina Rode, Louise Thelaus, Aida Yifter Lindgren, Alexandra Gabriela Ferreira, Rafael Brandão, Jonas Larsson, Marella de Bruijn, Javier Martin-Gonzalez, Carlos-Filipe Pereira

August 14, 2023 / 14:4645
Nature Communications

Restoring Tumor Immunogenicity with Dendritic Cell Reprogramming

Olga Zimmermannova, Alexandra G. Ferreira, Ervin Ascic, Marta Velasco Santiago, Ilia Kurochkin, Morten Hansen, Özcan Met, Inês Caiado, Ilja E. Shapiro, Justine Michaux, Marion Humbert, Diego Soto-Cabrera, Hreinn Benonisson, Rita Silvério-Alves, David Gomez-Jimenez, Carina Bernardo, Monika Bauden, Roland Andersson, Mattias Höglund, Kenichi Miharada, Yukio Nakamura, Stephanie Hugues, Lennart Greiff, Malin Lindstedt, Fábio F. Rosa, Cristiana F. Pires, Michal Bassani-Sternberg, Inge Marie Svane, Carlos-Filipe Pereira

July 7, 2023 / Vol. 8, Issue 85
Science Immunology

Single-Cell Transcriptional Profiling Informs Efficient Reprogramming of Human Somatic Cells to Cross-Presenting Dendritic Cells

Fábio F. Rosa, Cristiana F. Pires, Ilia Kurochkin, Evelyn Halitzki, Tasnim Zahan, Nejc Arh, Olga Zimmermannová, Alexandra G. Ferreira, Hongzhe Li, Stefan Karlsson, Stefan Scheding, Carlos-Filipe Pereira

March 4, 2022 / Vol. 7, No. 69
Science Immunology

Cell Fate Reprogramming in the Era of Cancer Immunotherapy

Olga Zimmermannova, Inês Caiado, Alexandra G. Ferreira and Carlos-Filipe Pereira

July 21, 2021 / Volume 12, Article 714822
Frontiers in Immunology

Mononuclear Phagocyte Regulation by the Transcription Factor Blimp-1 in Health and Disease

Isabel Ulmert, Luís Henriques‐Oliveira, Carlos‐Filipe Pereira, Katharina Lahl

August 16, 2020
Immunology

Direct Reprogramming of Mouse Embryonic Fibroblasts to Conventional Type 1 Dendritic Cells by Enforced Expression of Transcription Factors

Fábio F. Rosa, Cristiana F. Pires, Olga Zimmermannova and Carlos-Filipe Pereira

May 20, 2020 / Volume 10, Issue 10
Bio-protocol

A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells

Diana Pádua, Rita Barros, Ana Luísa Amaral, Patrícia Mesquita, Ana Filipa Freire, Mafalda Sousa, André Filipe Maia, Inês Caiado, Hugo Fernandes, António Pombinho, Carlos Filipe Pereira and Raquel Almeida

February 20, 2020 / Volume 12, Issue 2
Cancers

Is Immunotherapy the Holy Grail for Pancreatic Cancer?

Roland Andersson, Carlos-Filipe Pereira, Monika Bauden, Daniel Ansari

November 21, 2019 / Volume 11, Issue 17
Immunotherapy

Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors

Rita Silvério-Alves, Andreia M. Gomes, Ilia Kurochkin, Kateri A. Moore, Carlos-Filipe Pereira

November 4, 2019 / Issue 153
Journal of Visualized Experiments: Jove

Induction of Human Hemogenesis in Adult Fibroblasts by Defined Factors and Hematopoietic Coculture

Michael G. Daniel, David Sachs, Jeffrey M. Bernitz, Yesai Fstkchyan, Katrina Rapp, Namita Satija, Kenneth Law, Foram Patel, Andreia M. Gomes, Huen‐Suk Kim, Carlos‐Filipe Pereira Benjamin Chen, Ihor R. Lemischka, Kateri A. Moore

September 26, 2019 / 593(23):3266-3287
FEBS Letters

Direct Reprogramming of Fibroblasts into Antigen-Presenting Dendritic Cells

Fábio F. Rosa, Cristiana F. Pires, Ilia Kurochkin, Alexandra G. Ferreira, Andreia M. Gomes, Luís G. Palma, Kritika Shaiv, Laura Solanas, Cláudia Azenha, Dmitri Papatsenko, Oliver Schulz, Caetano Reis e Sousa and Carlos-Filipe Pereira

December 7, 2018 / Vol. 3, Issue 30, eaau4292
Science Immunology

Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming

Andreia M Gomes, Ilia Kurochkin, Betty Chang, Michael Daniel, Kenneth Law, Namita Satija, Alexander Lachmann, Zichen Wang, Lino Ferreira, Avi Ma'ayan, Benjamin K Chen, Dmitri Papatsenko, Ihor R Lemischka, Kateri A Moore, Carlos-Filipe Pereira

December 4, 2018 / Vol. 25, Issue 10
Cell Reports

Compositions for Reprogramming Cells into Dendritic Cells or Antigen Presenting Cells, Methods and Uses Thereof

Fábio F. Rosa, Cristiana F. Pires, Carlos-Filipe Pereira

October 13, 2018
Patent WO-2018-185709

High-throughput Identification of Small Molecules that Affect Human Embryonic Vascular Development

Helena Vazão, Susana Rosa, Tânia Barata, Ricardo Costa, Patrícia R. Pitrez, Inês Honório, Margreet R. de Vries, Dimitri Papatsenko, Rui Benedito, Daniel Saris, Ali Khademhosseini, Paul H. A. Quax, Carlos F. Pereira, Nadia Mercader, Hugo Fernandes, and Lino Ferreira

April 11, 2017 / Volume 114, Issue 15
PNAS

Method for Programming Differentiated Cells into Hematopoietic Stem Cells

Carlos-Filipe Pereira, Kateri A Moore, Ihor R. Lemischka

January 10, 2017
Patent WO-2013-116307

Hematopoietic Reprogramming In Vitro Informs In Vivo Identification of Hemogenic Precursors to Definitive Hematopoietic Stem Cells

Carlos-Filipe Pereira, Betty Chang, Andreia Gomes Jeffrey Bernitz, Dmitri Papatsenko, Xiaohong Niu, Gemma Swiers, Emanuele Azzoni, Marella F.T.R. de Bruijn, Christoph Schaniel, Ihor R. Lemischka, Kateri A. Moore

March 7, 2016 / Volume 36, Issue 5
Developmental Cell

Team